This study elaborates green synthesis, characterization, -phytochemical, antioxidant and antibacterial activities of copper and nickel metal nanoparticles. Copper chloride and nickel chloride were manipulated with a water-ethanol solvent in 1:1 to produce stable metallic nanoparticles using spinach and eucalyptus leaves extract to act as antioxidant and stabilizing agents. Techniques used for green synthesized metallic nanoparticles were done using UV-Vis Spectrophotometer, Fourier-Transform Infrared Spectroscopy (FTIR), X-ray Powder Diffraction (XRD) and Scanning Electron Microscopy (SEM). The phytochemical and antioxidant activities of spinach and eucalyptus leaves were performed. All prepared nanoparticles were screened against Candida albicans (Fungal Specie), Staphylococcus aureus, Escherichia coli, Salmonella choleraesuis, and Bacillus subtilis to investigate the antifungal as well as antibacterial activities. Satisfactory inhibition was recorded during Minimum Inhibitory Concentration (MIC) evaluation.