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020			_a9781319496504 (pbk)
040			_cPK-IsLIS
082			_a572 _bB4524
100			_aBerg, Jeremy M. & Gatto, Gregory J.
245		0	_aBiochemistry _c/ Jeremy M. Berg, John L. Tymoczko, Lubert Stryer
250			_a10th ed.
260			_bMacmillan Learning, _aNew York : _c2012.
300			_axxxvi, 1001 p.
505	0		_aContents Preface Acknowledgements About the Authors Chapter 1:- Biochemistry in Space and Time 1.1 Biochemical Unity Underlies Biological Diversity 1.2DNA Illustrates the Interplay between form and Function 1.3 Concepts from Chemistry Explain the Properties of Biological Molecules 1.4 DNA Sequencing is Transforming Biochemistry, Medicine and other Fields 1.5 Biochemistry is an Interconnected Human Endeavor Chapter 2:- Protein Composition and Structure 2.1 Several Properties of Proteins Structure 2.2 Proteins are Built from a Repertoire of 20 Amino Acids 2.3 Primary Structure Amino Acids are Linked by Peptide Bonds to Form Polypeptide Chains 2.4 Secondary Structure: Polypeptide Chains can Fold into regular Structures 2.5 Tertiary Structure: Proteins Can Fold into Globular or Fibrous Structures 2.6 Quaternary Structure: Polypeptide Chains can Assemble into multi-subunit structures 2.7 The Amino Acid Sequence of a Proteins Chapter 3:- Binding and Molecular Recognition 3.1 Binding is a Fundamental Process in Biochemistry 3.2 Myoglobin is an Efficient Oxygen 3.3 Hemoglobin is an Efficient Oxygen Carrier 3.4 The Immune System Depends on Key Binding Proteins 3.5 Quantitative Terms Can Describe Binding Propensity Chapter 4:- Protein Methods 4.1 The Purification of Proteins is an Essential First Step in Understanding Their Function 4.2 Immunology Provides important Techniques to Investigating Proteins 4.3 Mass Spectrometry is a powerful technique 4.4 Peptides can be Synthesized by Automated Solid Phase Methods 4.5 Three Dimensional Protein Structures can be Determined Experimentally Chapter 5:- Enzymes: Core Concepts and Kinetics 5.1 Enzymes are powerful and highly Specific Catalysts 5.2 Gibbs Free Energy is a useful Thermodynamic Function 5.3 Enzymes Accelerate Reactions by Facilitating the Formation of the Transition State Chapter 6:- Enzymes Catalytic Strategies 6.1 Enzymes use a Core Set of Catalytic Strategies 6.2 Proteases Facilitate a Fundamentally Difficult Reaction 6.3 Carbonic Anhydrases make a fast Reaction Faster 6.5 Molecular Motor Proteins Harness changes in Enzymes Chapter 7:- Enzyme Regulatory Strategies 7.1 Allosteric Regulation Enables Control of Metabolic Pathways 7.2 Isozymes Provide a means of regulation 7.3 Covalent Modification is a Means of Regulating Enzyme Activity 7.4 Many Enzymes are activated by specific Proteolytic Cleavage 7.5 Enzymatic Cascades Allow Rapid Responses Such as Blood Clotting Chapter 8:- DNA, RNA and the Flow of Genetic Information 8.1 A Nucleic Acid consists of Four Kinds 8.2 A pair of Nucleic Acid Stands with Complementary Sequences 8.3 The Double Helix Facilitates the Accurate Transmission of Heredity Information 8.4 DNA is replicated by polymerases that take Instructions from Templates 8.5 Gene Expression is the Transformation of DNA Information into Functional Molecules Chapter 9 :- Nucleic Acid Methods 9.1 The Exploration of Genes Relies on Key Tools 9.2 Recombinant DNA Technology has Revolutionized All aspects of Biology 9.3 Complete Genomes have been sequenced and analyzed 9.4 Eukaryotic Genes can be Quantitated and Manipulated with Considerable Precision Chapter 10:- Exploring Evolution and Bioiformatics 10.1 Homologs are Descended from a Common Ancestor 10.2 Examination of Three Dimensional Structure Enhances our Undestanding of Evolutionary Relationships 10.3 Evolutionary Trees can be Constructed on the basis of Sequence Information 10.4 Lectins are Specific Carbohydrate-Binding Proteins Chapter 12:- Lipid and Biological Membranes 12.1 Fatty Acids are Key Constituents of Lipids 12.2 Biological Membranes are composed of Three Common types of Membranes Lipids 12.3 Phospholipids and Glycolipids Readily form Bimolecular Sheets in Aqueos Media Chapter 13:- Membrane Channels and Pumps 13.1 The Transport of Molecules Across a Membrane 13.2 Two Families of Membrane Protiens Use ATP Hydrolysis to actively Transport Ions and Molecules Across membranes 13.3 Lactose Permease is an Archetype of Secondary Transporters 13.4 Specific Channels can rapidly transport Ions Across Membranes 13.5 GAP ?Junctions Allow Ions and Small Molecules to Flow between Communicating Cells Chapter 14:- Signals - Transduction Pathways 14.1 Many Signals - Transduction Pathways share common Themes 14.2 Epinephrine Signaling Heterotrimeric G Proteins Transmit Signals and Reset Themselves 14.3 Insulin Signaling: Phosphorylation Cascades are Central to Many Transduction Processes 14.4 Epidermal Growth Factor REceptor Dimerization can Drive Signals 14.5 Defects in Signal-Transduction Pathways can lead to Cancer and Other Diseases Chapter 15:- Metabolism: Basic Concepts and Themes 15.1 Metabolism is composed of many interconnected reactions 15.2 ATP is the Universal Currency of Free Energy in Biological Systems 15.3 The Oxidation of Carbon Fuels is an important Source of Cellular Energy 15.4 Metabolic Pathways Contain many Recurring Motifs Chapter 16:- Glycolysis and Gluconeogenesis 16.1 Glycolysis is an energy Conversion Pathway in Most Organisms 16.2 Glycolysis can be Divided into Two Parts 16.3 The Glycolytic Pathway is Tightly Controlled 16.4 Glucose Can be Synthesized from Non-carbohydrate Precursors 16.5 Gluconeogenesis and Glycolysis are Reciprocally Regulated Chapter 17:- Pyruvate Dehydrogenase and the Citric Acid Cycle 17.1 The Citric Acid Cycle Harvests High Energy Electrons 17.2 The Pyruvate Dehydrogenase Complex Links Glycolysis to the Citric Acid Cycle 17.3 The Citric Acid Cycle Oxidizes Two Carbon Units 17.4 Entry to the Citric Acid Cycle and Metabolism Through It are Controlled 17.5 The Citric Acid Cycle is a Source of Biosynthetic Precursors Chapter 18:- Oxidative Phosphorylation 18.1 Cellular Respiration Drives ATP Formation by Transferring Electrons to Molecular Oxygen 18.2 Oxidative Phosphorylation depends on Electron Transfer 18.3 The Respiratory Chain Consists of Four Complexes 18.4 A Proton Gradients Powers the syntheses of ATP 18.5 Manu Shuttles Allow Movement Across Mitochondrial Membranes Chapter 19:- Phototrophy and the Light Reactions of Photosynthesis 19.1 Phototrophy converts Light Energy into Chemical Energy 19.2 In Eukaryotes, Photosynthesis Takes Place in Chloroplasts 19.3 Light Obsorption by Chlorophyll Molecules Induces Electron Transfer 19.4 Two Photosystems Generate a Proton Gradient 19.5 A Proton Gradient Across the Thylakoid Membrane Drives ATP Synthesis Chapter 20:- The Calvin - Benson Cycle and the Pentose Phosphate Pathway 20.1 The Calvin-Benson Cycle Synthesizes Hexoses from Carbon Dioxide and Water 20.2 The Activity of the Calvin-Benson Cycle Depends on Environmental Conditions 20.3 The Pentose Phosphate Pathway Generates NADPH and Synthesizes Pentoses 20.4 The Metabolism of Glucose 6-Phosphate by the Pentose Phosphate Pathway is coordinated with Glyclysis 20.5 Glucose Phosphate Dehydrogenase Plays a Key role in Protection against Reactive Oxygen Species Chapter 21:- Glycogen Metabolism 21.1 Glycogen Metabolism is the Regulated Release and Storage of Glucose in Multiple Tissues 21.2 Glycogen Breakdown requires the Interplay of Several Enzymes 21.3 Phosphorylase is Regulated by Allosteric Interactions and Controlled by Reversible Phosphorylation 21.4 Glucagon and Epinephrine Signal the need for Glycogen Breakdown 21.5 Glycogen Synthesis Requires Several Enzymes and Uridine Diphosphate Glucose Chapter 22:- Fatty Acid and Triacylglycerol Metabolism Chapter 23:- Protein Turnover and Amino Acid Catabolism Chapter 24:- Integration of Energy Metabolism Chapter 25:- Biosynthesis of Amino Acid Chapter 26:- Nucleotide Biosynthesis Chapter 27:- Biosynthesis of Membrane Lipids and Steroids Chapter 28:- DNA Replication, Repair, and Recombination Chapter 29:- RNA Functions, Biosynthesis and Processing Chapter 30:- Protein Biosynthesis Chapter 31:- Control of Gene Expression Chapter 32:- Principles of Drug Discovery and Development Chemistry Review Appendix Answers to Self Check Questions Answers to Problems Index
650			_aBiochemistry
942			_cBK
999			_c24117 _d24116