000			02139nam a22001697a 4500
999			_c21875 _d21875
005			20221018173848.0
008			221018b ||||| |||| 00| 0 eng d
020			_ahbk
082			_a591 _bAs743
100			_aYusra Baig, _bBS Zoology, _c2015-2019, _dSupervised by Dr. Asma Chaudhary
245			_aAssessment of the antimicrobial potential of synthetic wchief bases and their metal complexes _c/ Yusra Baig
260			_aLahore : _bDivision of Science & Technology, University of Education, _c2019
300			_ax, 67 p. _eCD
520			_aThe antimicrobial activity of the synthesized derivatives (collected from chemistry department) was evaluated using a broth dilution method against bacterial pathogens. The concentration of compounds was 1.5mg/ml. Ciprofloxacin was a reference compound to be used as positive control. The compounds exhibited percent antibiosis against Escherichia coli (37.40-99.83), Pseudomonas aeruginosa (0-99.51),Staphylococus aureus (27.12-99.42) and Klebsiella sp. (7.80-99.82).2,2'-((1E,1'E)-(1,2- phenylenebis(azanylylidene))bis(methanylylidene))diphenol(AS-42) and 2-((E)-2-((2- ((E)-(2-hydroxybenzylidene)amino)-ethyl)imino)ethyl)phenol zinc(II)(AS-51) showed antibiosis (90%) against Klebsiella sp. and S.aureus. 2,2'-((1E,1'E)-(1,2- phenylenebis(azanylylidene))-bis(methanylylidene))diphenolzinc(II)(AS-46) showed maximum antibiotic potential (99%) against (Escherichia coli and Pseudomonas aeruginosa).2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene)) diphenolcobalt(II(AS-45), Bis((E)-2-((pyrimidin-2-ylimino)methyl)phenol)copper(II) (AS-54), Bis((E)-2-((pyrimidin-2-ylimino)methyl)phenol)plumb(II)(AS-53) were resistant to P.aeruginosa whereas susceptible to other three pathogens. Analysis of the structure-activity relationship showed that testing Schiff bases lead to more potent derivatives with a broader spectrum of antibacterial activity. Key words: Schiff bases, metallic complexes and Schiff base, clinical and susceptibility testing. Multi drug resistance, Antimicrobial agents, antibiosis
650			_aZoology--Antimicrobial--Synthetic
942			_cTH