000			02560nam a22001697a 4500
999			_c21869 _d21869
005			20221018164002.0
008			221018b ||||| |||| 00| 0 eng d
020			_ahbk
082			_a591 _bB5211
100			_aAqsa Ashraf, _bBS Zoology, _c2015-2019, _dSupervised by Dr. Asma Chaudhary
245			_aBiological screening of synthetic compounds having azomethine linkage _c/ Aqsa Ashraf
260			_aLahore : _bDivision of Science & Technology, University of Education, _c2019
300			_aix, 58 p. _eCD
520			_aThe Schiff base ligand and its metal complexes were designed and collected from Chemistry department as potential antimicrobial agent and structure activity relationship could be established following in vitro assays against human pathogens. The broth dilution method was used to determine percent antibiosis. Testing compounds were diluted upto 1.5mg/ml. Ciprofloxacin was used as a positive control. Most of the chemicals inhibited the growth of all pathogens but percentage of antibiosis varied for different pathogens. The Schiff bases and their derivatives exhibited percent antibiosis against Escherichia coli (23.67-99.15), Pseudomonas aeruginosa (32.36-99.49), Staphylococcus aureus (33.19-99.26) and klebsiella sp. (20.93-99.51). The Bis((N1E,N2E)-N1,N2-bis(4-methoxybenzylidene)-benzene-1,2-diamine)plumbum (II)acetate (MS-89) and Bis(3-(1-(4 hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one nickel(II)nitrate (AK-25) showed better antibiotic potential (›90%) against two pathogens i.e; E. coli and Klebsiella sp. But Bis(3-(1-(4 hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one nickel(II)nitrate (AK-25) showed no activity against P. aeruginosa. Yet, the (E)-N-(2- nitrobenzylidene) 3-nitroaniline (AH-4B) exhibited highest percent antibiosis (›90%) with two pathogens (P. aeruginosa and S. aureus). The 3-(1-(4- hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one (AK-22) inhibited four pathogens in range of 68-83%. The two pathogens i.e; P. aeruginosa and S. aureus developed resistance against Bis(3-(1-(2-(2,4dinitrophenyl)hydrazono)ethyl)dihydrofuran-2(3H)- one)cobalt(II)chloride (AK-19). The compounds (MS-89, AH-4B) with better antibiosis against four human pathogens can be used as chemotherapeutic agent in pharmaceutical industry ton treat pathogenic infectious diseases. Key Word: Schiff base, P. aeruginosa, S. aureus, Klebsiella, E.coli, Antimicrobial activity, Percent inhibition, Bacterial potential.
650			_aZoology--Biological Screening--Synthetic Compounds--Azomethine
942			_cTH