Iram Mukhtar,  BS Zoology,  2015-2019,  Supervised by Dr. Asma Chaudhary <br/><br/>
Evaluation of bacterial growth inhibition against divalent metallic compounds of schiff base 
/ Iram Mukhtar 
 - Lahore :  Division of Science & Technology, University of Education,   2019 
 - x, 60 p.   CD 
<br/><br/> The Schiff base ligand, and its metal complexes were designed and collected from<br/>Chemistry department as potential antimicrobial agents, and bioactivity could be<br/>determined following in vitro assays against human pathogens. The broth dilution method<br/>was used to determine percent antibiosis. Ten testing compounds were diluted up to<br/>1.5mg/ml. Ciprofloxacin was used as positive control. The compounds exhibited<br/>moderate to good percent antibiosis against Escherichia coli (44.48-99.73), Pseudomonas<br/>aeruginosa (31.4-99.28), Staphylococcus aureus (27.12-99.68) and Klebsiella sp. (39.53-<br/>99.84). Bis((N1Z,N2Z)-N1,N2-dibenzylideneethane-1,2-diamine)plumbum(II)acetate<br/>(MS-84) showed better antibiotic potential against four pathogens (Escherichia coli,<br/>Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella sp. with the percent<br/>antibiosis ranging from 81.22-99.39. Controversially, 3,3'-((1Z,1'Z)-(ethane-1,2-<br/>diylbis(azanylylidene))-bis(methanylylidene))diphenolcopper(II) (MS-80) inhibited two<br/>pathogens (Pseudomonas aeruginosa, Klebsiella sp. with less than 20% antibiosis while<br/>showed better antibiotic activity (>90) against other two pathogens (Staphylococcus<br/>aureus, Escherichia coli. Two designed Schiff bases i-e MS-84 and MS-80 will be<br/>promising therapeutant to be used in pharmaceutical industry.<br/>Key words:- Divalent metal complexes, Schiff base ligands, antibacterial activity, Broth<br/>dilution method, Human pathogens, antibiosis. 
<br/><br/><label>ISBN: </label>hbk 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Zoology--Evaluation--Bacterial Growth--Metallic Compounds
<br/><br/><label>Dewey Class. No.: </label>591  / Ev132