01445cam a22002774a 4500 16273 16273 15810304 20200907113423.0 090709s2010 flua b 001 0 eng 9781420070996 (hardcover : alk. paper) DLC 615.19 22 M3791 Martin, Yvonne Connolly, Quantitative drug design : a critical introduction / Yvonne Connolly Martin. 2nd ed. Boca Raton : CRC Press/Taylor & Francis, 2010 xv, 282 p. : ill. ; 25 cm. Drugs Structure-activity relationships. QSAR (Biochemistry) Drugs Design. Drug Design. Biopharmaceutics. Models, Theoretical. Quantitative Structure-Activity Relationship. BK 1. Overview of quantitative drug design 2. Noncovalent interactions in biological systems 3. Preparation of 3d structures of molecules for 3d qsar 4. Calculating physical properties of molecules 5. Biological data 6. Form of equations relating potency and physical properties 7. Statistical basis of regression and partial least-squares analysis 8. Strategy for the statistical evaluation of a data set of related molecules 9. Detailed examples of qsar calculations on erythromycin esters 10. Case studies 11. Methods to approach other structure-activity problems. 0 0 0 0 LIST LIST 2018-11-26 U.E.24338 0 615.19 M3791 T9877 2018-11-26 00:00:00 2018-11-26 BK