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Title; Copyright; Preface; Introduction; 1 Ion Sources; 1.1 Electron Ionization; 1.2 Chemical Ionization; 1.3 Field Ionization; 1.4 Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry; 1.5 Field Desorption; 1.6 Plasma Desorption; 1.7 Laser Desorption; 1.8 Matrix-Assisted Laser Desorption Ionization; 1.9 Thermospray; 1.10 Atmospheric Pressure Ionization; 1.11 Electrospray; 1.12 Atmospheric Pressure Chemical Ionization; 1.13 Atmospheric Pressure Photoionization; 1.14 Atmospheric Pressure Secondary Ion Mass Spectrometry; 1.15 Inorganic Ionization Sources. 1.16 Gas-Phase Ion-Molecule Reactions1.17 Formation and Fragmentation of Ions: Basic Rules; 2 Mass Analysers; 2.1 Quadrupole Analysers; 2.2 Ion Trap Analysers; 2.3 The Electrostatic Trap or 'Orbitrap'; 2.4 Time-of-Flight Analysers; 2.5 Magnetic and Electromagnetic Analysers; 2.6 Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry; 2.7 Hybrid Instruments; 3 Detectors and Computers; 3.1 Detectors; 3.2 Computers; 4 Tandem Mass Spectrometry; 4.1 Tandem Mass Spectrometry in Space or in Time; 4.2 Tandem Mass Spectrometry Scan Modes. 4.3 Collision-Activated Decomposition or Collision-Induced Dissociation4.4 Other Methods of Ion Activation; 4.5 Reactions Studied in MS/MS; 4.6 Tandem Mass Spectrometry Applications; 5 Mass Spectrometry/Chromatography Coupling; 5.1 Elution Chromatography Coupling Techniques; 5.2 Chromatography Data Acquisition Modes; 5.3 Data Recording and Treatment; 6 Analytical Information; 6.1 Mass Spectrometry Spectral Collections; 6.2 High Resolution; 6.3 Isotopic Abundances; 6.4 Low-mass Fragments and Lost Neutrals; 6.5 Number of Rings or Unsaturations. 6.6 Mass and Electron Parities, Closed-shell Ions and Open-shell Ions6.7 Quantitative Data; 7 Fragmentation Reactions; 7.1 Electron Ionization and Fragmentation Rates; 7.2 Quasi-Equilibrium and RRKM Theory; 7.3 Ionization and Appearance Energies; 7.4 Fragmentation Reactions of Positive Ions; 7.5 Fragmentation Reactions of Negative Ions; 7.6 Charge Remote Fragmentation; 7.7 Spectrum Interpretation; 8 Analysis of Biomolecules; 8.1 Biomolecules and Mass Spectrometry; 8.2 Proteins and Peptides; 8.3 Oligonucleotides; 8.4 Oligosaccharides; 8.5 Lipids; 8.6 Metabolomics; 9 Exercises; Questions. AnswersAppendices; 1 Nomenclature; 2 Acronyms and abbreviations; 3 Fundamental Physical Constants; 4A Table of Isotopes in Ascending Mass Order; 4B Table of Isotopes in Alphabetical Order; 5 Isotopic Abundances (in %) for Various Elemental Compositions CHON; 6 Gas-Phase Ion Thermochemical Data of Molecules; 7 Gas-Phase Ion Thermochemical Data of Radicals; 8 Literature on Mass Spectrometry; 9 Mass Spectrometry on Internet; Index.