Chalcones are the predecessors of flavonoids which constitute most of the edible plants, and their derivatives such as pyrazolic chalcones have encouraged the attention owing to their highly active pharmacological, biological and industrial applications. A change in their structures has presented a high level of multiplicity which is worthwhile for the advancement of novel therapeutic agents having enriched potential and reduced noxiousness. The current work highlights the synthesis of various substituted chalcones and respective pyrazolic chalcones using Claisen-Schmidt condensation of substituted aldehydes and ketones. EIMS and IR spectroscopy were used for characterization and structure elucidation of the synthesized compounds. Their peaks showed clear clues for the production of desired products with maximum yields (70-80%). Their bioscreening test (FRAP, DPPH) was performed to check out anti-oxidant activity against different bacterial strains. The compounds 4d showed maximum reduction potential and 3b showed the least. 4a exhibited maximum radical scavenging and 4e showed minimum zone of inhibition against bacterial strains. This research provides inexpensive, reliable and accurate methods of synthesis for chalcones in the laboratory practices. The products obtained are valuable synthon in Supramolecular and Material Chemistry.