Synthesis, Characterization and Bioscreening of Isoxazolic Aurone Analogues /Ayesha Kanwal
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TextPublication details: Lahore : Department of Chemistry, Div. S&T, University of Education, 2017Description: 77 p. xii CDSubject(s): DDC classification: - 547.2 Sy78
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Theses
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UE-Central Library | 547.2 Sy78 (Browse shelf(Opens below)) | Not for loan | TTH21 |
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Several substituted chalcones, aurones and isoxazolic aurones were synthesized. 2'-hydroxy acetophenone and various substituted benzaldehyde were used as precursor to synthesize chalcones. Synthesized chalcones on oxidative cyclization in presence of mercury (II) acetate in pyridine yielded aurones. Respective aurones were treated with hydroxylamine hydrochloride in ethanolic potassium hydroxide to form final
isoxazolic aurones. Synthesized compounds were bioscreened for exhibiting antioxidant activity. Among all, some compounds were found to have potent anti-oxidant activity. Compound 5c was found to exhibit maximum radical scavenging and reduction potential. 7b showed lowest radical scavenging activity while 3c showed lowest reduction potential. Structure of compounds has been confirmed by IR and EIMS.
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