Assessment of the antimicrobial potential of synthetic wchief bases and their metal complexes (Record no. 21875)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02139nam a22001697a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221018173848.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221018b ||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | hbk |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 591 |
| Item number | As743 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Student name | Yusra Baig, |
| Class | BS Zoology, |
| Session | 2015-2019, |
| Supervisor | Supervised by Dr. Asma Chaudhary |
| 245 ## - TITLE STATEMENT | |
| Title | Assessment of the antimicrobial potential of synthetic wchief bases and their metal complexes |
| Statement of responsibility, etc | / Yusra Baig |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Lahore : |
| Name of publisher, distributor, etc | Division of Science & Technology, University of Education, |
| Date of publication, distribution, etc | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | x, 67 p. |
| Accompanying material | CD |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | The antimicrobial activity of the synthesized derivatives (collected from chemistry<br/>department) was evaluated using a broth dilution method against bacterial pathogens. The<br/>concentration of compounds was 1.5mg/ml. Ciprofloxacin was a reference compound to<br/>be used as positive control. The compounds exhibited percent antibiosis against<br/>Escherichia coli (37.40-99.83), Pseudomonas aeruginosa (0-99.51),Staphylococus<br/>aureus (27.12-99.42) and Klebsiella sp. (7.80-99.82).2,2'-((1E,1'E)-(1,2-<br/>phenylenebis(azanylylidene))bis(methanylylidene))diphenol(AS-42) and 2-((E)-2-((2-<br/>((E)-(2-hydroxybenzylidene)amino)-ethyl)imino)ethyl)phenol zinc(II)(AS-51) showed<br/>antibiosis (90%) against Klebsiella sp. and S.aureus. 2,2'-((1E,1'E)-(1,2-<br/>phenylenebis(azanylylidene))-bis(methanylylidene))diphenolzinc(II)(AS-46) showed<br/>maximum antibiotic potential (99%) against (Escherichia coli and Pseudomonas<br/>aeruginosa).2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))<br/>diphenolcobalt(II(AS-45), Bis((E)-2-((pyrimidin-2-ylimino)methyl)phenol)copper(II)<br/>(AS-54), Bis((E)-2-((pyrimidin-2-ylimino)methyl)phenol)plumb(II)(AS-53) were<br/>resistant to P.aeruginosa whereas susceptible to other three pathogens. Analysis of the<br/>structure-activity relationship showed that testing Schiff bases lead to more potent<br/>derivatives with a broader spectrum of antibacterial activity.<br/>Key words: Schiff bases, metallic complexes and Schiff base, clinical and susceptibility<br/>testing. Multi drug resistance, Antimicrobial agents, antibiosis |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Zoology--Antimicrobial--Synthetic |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Theses |
| Withdrawn status | Damaged status | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| UE-Central Library | UE-Central Library | 18.10.2022 | 591 As743 | TTH185 | 18.10.2022 | 18.10.2022 | Theses |
