Biological screening of synthetic compounds having azomethine linkage (Record no. 21869)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02560nam a22001697a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221018164002.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221018b ||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | hbk |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 591 |
| Item number | B5211 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Student name | Aqsa Ashraf, |
| Class | BS Zoology, |
| Session | 2015-2019, |
| Supervisor | Supervised by Dr. Asma Chaudhary |
| 245 ## - TITLE STATEMENT | |
| Title | Biological screening of synthetic compounds having azomethine linkage |
| Statement of responsibility, etc | / Aqsa Ashraf |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Lahore : |
| Name of publisher, distributor, etc | Division of Science & Technology, University of Education, |
| Date of publication, distribution, etc | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | ix, 58 p. |
| Accompanying material | CD |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | The Schiff base ligand and its metal complexes were designed and collected from<br/>Chemistry department as potential antimicrobial agent and structure activity relationship<br/>could be established following in vitro assays against human pathogens. The broth<br/>dilution method was used to determine percent antibiosis. Testing compounds were<br/>diluted upto 1.5mg/ml. Ciprofloxacin was used as a positive control. Most of the<br/>chemicals inhibited the growth of all pathogens but percentage of antibiosis varied for<br/>different pathogens. The Schiff bases and their derivatives exhibited percent antibiosis<br/>against Escherichia coli (23.67-99.15), Pseudomonas aeruginosa (32.36-99.49),<br/>Staphylococcus aureus (33.19-99.26) and klebsiella sp. (20.93-99.51). The<br/>Bis((N1E,N2E)-N1,N2-bis(4-methoxybenzylidene)-benzene-1,2-diamine)plumbum (II)acetate<br/>(MS-89) and Bis(3-(1-(4 hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one nickel(II)nitrate<br/>(AK-25) showed better antibiotic potential (›90%) against two pathogens i.e; E. coli and<br/>Klebsiella sp. But Bis(3-(1-(4 hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one<br/>nickel(II)nitrate (AK-25) showed no activity against P. aeruginosa. Yet, the (E)-N-(2-<br/>nitrobenzylidene) 3-nitroaniline (AH-4B) exhibited highest percent antibiosis (›90%) with<br/>two pathogens (P. aeruginosa and S. aureus). The 3-(1-(4-<br/>hydroxyphenylimino)ethyl)dihydrofuran-2(3H)-one (AK-22) inhibited four pathogens in<br/>range of 68-83%. The two pathogens i.e; P. aeruginosa and S. aureus developed<br/>resistance against Bis(3-(1-(2-(2,4dinitrophenyl)hydrazono)ethyl)dihydrofuran-2(3H)-<br/>one)cobalt(II)chloride (AK-19). The compounds (MS-89, AH-4B) with better antibiosis<br/>against four human pathogens can be used as chemotherapeutic agent in pharmaceutical<br/>industry ton treat pathogenic infectious diseases.<br/>Key Word: Schiff base, P. aeruginosa, S. aureus, Klebsiella, E.coli, Antimicrobial<br/>activity, Percent inhibition, Bacterial potential. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Zoology--Biological Screening--Synthetic Compounds--Azomethine |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Theses |
| Withdrawn status | Damaged status | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| UE-Central Library | UE-Central Library | 18.10.2022 | 591 B5211 | TTH179 | 18.10.2022 | 18.10.2022 | Theses |
