Method Development and Validation of Levofloxacin Injection by UV-Spectrophotometer (Record no. 21596)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01791nam a22001577a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923142221.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220719b ||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 543 |
| Item number | M5661 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Student name | Sadaf Javaid, |
| Class | Msc(chemistry) |
| Session | 2016-2018 |
| Supervisor | Supervised by Dr.Asad Gulzar |
| 245 ## - TITLE STATEMENT | |
| Title | Method Development and Validation of Levofloxacin Injection by UV-Spectrophotometer |
| Statement of responsibility, etc | /Sadaf Javaid |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Lahore : |
| Name of publisher, distributor, etc | Department of Chemistry, Div. S&T, University of Education, |
| Date of publication, distribution, etc | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 57 p. |
| Accompanying material | CD |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Levofloxacin is a third generation antibiotic belongs to a subset fluoroquinolone, extensively studied and applied in biomedical field of sciences. The main focus of presented research work was to develop an analytical methodology using UV spectrophotometer for the validation of levofloxacin in pharmaceutical injectable formulations (Leflox). Different validation parameters were performed using 0.1N HCl as diluent, for levofloxacin. The results of all these performed parameters were found within acceptable ranges, as provided by ICH guidelines. The developed methodology was linear in examined range of 3-7µg/mL with correlation coefficient (0.99997). The absorbance maxima for levofloxacin was measured at 293nm using 0.1N HCl as a blank. The precision and recovery studies were performed and results were found in close agreement with the values designed by ICH. The % RSD was found 0.00223% for precision and 0.001639-0.001641% for intermediate precision. The calculated mean percentage recovery was found to be 99.92 to 100.05%, indicated that the investigated method was established and implemented successfully for routine validation or analytical assessment of levofloxacin in injectable form. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Levofloxacin - UV-Spectrophotometer - Chemistry |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Theses |
| Withdrawn status | Damaged status | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| UE-Central Library | UE-Central Library | 19.07.2022 | 543 M5661 | TTH29 | 19.07.2022 | 19.07.2022 | Theses |
