Bio Screening of Chalcones and Aurones Analogues
Urooj Fatima Dilawari, MPhil(Zoology) 2015-2018 Supervised by Dr.Muhammad Mansha
Bio Screening of Chalcones and Aurones Analogues /Urooj Fatima Dilawari - Lahore : Department of Zoology, Div. S&T University of Education, 2018 - 80 p. xi CD
Chalcones and Aurones are synthetic compounds having appealing pharmacological profile. The Chalcones and Aurones were biologically active due to the presence of carbonyl system. The antibacterial and antifungal properties of chalcones and aurones were determined in this study. The Chalcones derivatives were numbered as 1,2,3,4,5,6,7,8 and 9 whereas the Aurones derivatives were marked as 1,2,3 and 4. The bio screening was conducted and assessed against Staphylococcus aureus (S. aureus), Candida albicans(C. albicans) and Escherichia coli (E. coli) by agar well diffusion method. The micro-organism inoculums were uniformly spread with sterile cotton swab on the agar plates. The 6mm diameter wells were formed with Pasteur pipettes. In each well 10µg of each derivative compound was added. The incubation period for petri plates was 1 day at 37˚C. After incubation Bacterial and Fungal growth was studied by measuring the inhibition growth zone. The results showed that among the Chalcone derivatives, (E)-3- (2,3- dimethoxyphenyl)-1- phenylprop-2-en-1-one and (E)-3- (2-methoxyphenyl)-1- phenylprop-2-en-1-one were found inactive, whereas derivatives (E)- chalcone, (E)-3- (3- methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (3,4-dimethoxyphenyl)-1- phenylprop2-en-1-one, (E)-3- (4-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (3-nitrophenyl) - 1-phenylprop-2-en-1-one and (E)-1-phenyl -3- (2,3,4-dimethoxyphenyl)prop -2-en-1-one showed insignificant activity and derivative (E)-3- (3-chlorophenyl)-1- phenylprop-2-en1-one showed moderate activity against E. coli. Similarly compounds (E) -3-(3- chlorophenyl)-1- phenylprop-2-en-1-one and (E)-3- (2-methoxyphenyl)-1- phenylprop-2- en-1-one were found inactive, while compounds (E)- chalcone, (E)-3- (3- X methoxyphenyl) -1-phenylprop-2-en-1-one,(E)-3-(4-methoxyphenyl) -1- phenylprop-2 - en-1-one,(E) -1-phenyl-3- (2,3,4-dimethoxyphenyl)prop -2-en-1-one and(E)-3-(3- nitrophenyl) -1-phenylprop-2-en-1-one showed insignificant activity and compound (E)- 3-(3,4-dimethoxyphenyl) -1-phenylprop-2-en-1-one and (E)-3- (2,3-dimethoxyphenyl) - 1-phenylprop-2-en-1-one displayed moderate activity against S. aureus. Compound (E)- 3- (3-nitrophenyl)-1 -phenylprop-2-en-1-one was found inactive, whereas compound (E)- 1-phenyl-3- (2,3,4-dimethoxyphenyl) prop-2-en-1-one, (E)-3-(2-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (4-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)- chalcone, (E)-3- (2,3-dimethoxyphenyl)-1- phenylprop-2-en-1-one, and (E)-3- (3- chlorophenyl)-1- phenylprop-2-en-1-one showed insignificant activity and compound (E)-3- (3-methoxyphenyl)-1- phenylprop-2-en-1-one and (E)-3- (3,4-dimethoxyphenyl)- 1- phenylprop-2-en-1-one reflected moderate activity against C. albicans. Among the Aurone derivatives, compound (Z)-2- (4-methoxybenzylidene) benzofuran-3(2H)-one was inactive, compounds (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)-one and (Z)-2- (3-methoxybenzylidene) benzofuran-3(2H)-one showed insignificant activity and compound (Z)-2-benzylidenebenzofuran-3(2H)-one showed significant activity against E. coli. Compound (Z)-2-(3-methoxybenzylidene) benzofuran-3(2H)-one was inactive, compounds (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)-one, (Z)-2-(4-methoxybenzylidene) benzofuran-3(2H)-one showed moderate activity and compound (Z)-2-benzylidenebenzofuran-3(2H)-one showed very effective activity against S. aureus. Similarly, compound (Z)-2-(3-methoxybenzylidene) benzofuran-3(2H)-one was found inactive, while compounds (Z)-2- benzylidenebenzofuran-3(2H)-one, (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)- XI one, (Z)-2-(4-methoxybenzylidene) benzofuran-3(2H)-one showed moderate activity against C. albicans. Taken together, very few derivatives of Chalcone, Aurone and their derivatives were significantly effective against selected bacteria and fungi strains
Bio Screening - Chalcones - Aurones Analogues - Zoology
591 / B5201
Bio Screening of Chalcones and Aurones Analogues /Urooj Fatima Dilawari - Lahore : Department of Zoology, Div. S&T University of Education, 2018 - 80 p. xi CD
Chalcones and Aurones are synthetic compounds having appealing pharmacological profile. The Chalcones and Aurones were biologically active due to the presence of carbonyl system. The antibacterial and antifungal properties of chalcones and aurones were determined in this study. The Chalcones derivatives were numbered as 1,2,3,4,5,6,7,8 and 9 whereas the Aurones derivatives were marked as 1,2,3 and 4. The bio screening was conducted and assessed against Staphylococcus aureus (S. aureus), Candida albicans(C. albicans) and Escherichia coli (E. coli) by agar well diffusion method. The micro-organism inoculums were uniformly spread with sterile cotton swab on the agar plates. The 6mm diameter wells were formed with Pasteur pipettes. In each well 10µg of each derivative compound was added. The incubation period for petri plates was 1 day at 37˚C. After incubation Bacterial and Fungal growth was studied by measuring the inhibition growth zone. The results showed that among the Chalcone derivatives, (E)-3- (2,3- dimethoxyphenyl)-1- phenylprop-2-en-1-one and (E)-3- (2-methoxyphenyl)-1- phenylprop-2-en-1-one were found inactive, whereas derivatives (E)- chalcone, (E)-3- (3- methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (3,4-dimethoxyphenyl)-1- phenylprop2-en-1-one, (E)-3- (4-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (3-nitrophenyl) - 1-phenylprop-2-en-1-one and (E)-1-phenyl -3- (2,3,4-dimethoxyphenyl)prop -2-en-1-one showed insignificant activity and derivative (E)-3- (3-chlorophenyl)-1- phenylprop-2-en1-one showed moderate activity against E. coli. Similarly compounds (E) -3-(3- chlorophenyl)-1- phenylprop-2-en-1-one and (E)-3- (2-methoxyphenyl)-1- phenylprop-2- en-1-one were found inactive, while compounds (E)- chalcone, (E)-3- (3- X methoxyphenyl) -1-phenylprop-2-en-1-one,(E)-3-(4-methoxyphenyl) -1- phenylprop-2 - en-1-one,(E) -1-phenyl-3- (2,3,4-dimethoxyphenyl)prop -2-en-1-one and(E)-3-(3- nitrophenyl) -1-phenylprop-2-en-1-one showed insignificant activity and compound (E)- 3-(3,4-dimethoxyphenyl) -1-phenylprop-2-en-1-one and (E)-3- (2,3-dimethoxyphenyl) - 1-phenylprop-2-en-1-one displayed moderate activity against S. aureus. Compound (E)- 3- (3-nitrophenyl)-1 -phenylprop-2-en-1-one was found inactive, whereas compound (E)- 1-phenyl-3- (2,3,4-dimethoxyphenyl) prop-2-en-1-one, (E)-3-(2-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)-3- (4-methoxyphenyl)-1- phenylprop-2-en-1-one, (E)- chalcone, (E)-3- (2,3-dimethoxyphenyl)-1- phenylprop-2-en-1-one, and (E)-3- (3- chlorophenyl)-1- phenylprop-2-en-1-one showed insignificant activity and compound (E)-3- (3-methoxyphenyl)-1- phenylprop-2-en-1-one and (E)-3- (3,4-dimethoxyphenyl)- 1- phenylprop-2-en-1-one reflected moderate activity against C. albicans. Among the Aurone derivatives, compound (Z)-2- (4-methoxybenzylidene) benzofuran-3(2H)-one was inactive, compounds (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)-one and (Z)-2- (3-methoxybenzylidene) benzofuran-3(2H)-one showed insignificant activity and compound (Z)-2-benzylidenebenzofuran-3(2H)-one showed significant activity against E. coli. Compound (Z)-2-(3-methoxybenzylidene) benzofuran-3(2H)-one was inactive, compounds (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)-one, (Z)-2-(4-methoxybenzylidene) benzofuran-3(2H)-one showed moderate activity and compound (Z)-2-benzylidenebenzofuran-3(2H)-one showed very effective activity against S. aureus. Similarly, compound (Z)-2-(3-methoxybenzylidene) benzofuran-3(2H)-one was found inactive, while compounds (Z)-2- benzylidenebenzofuran-3(2H)-one, (Z)-2-(2-methoxybenzylidene) benzofuran-3(2H)- XI one, (Z)-2-(4-methoxybenzylidene) benzofuran-3(2H)-one showed moderate activity against C. albicans. Taken together, very few derivatives of Chalcone, Aurone and their derivatives were significantly effective against selected bacteria and fungi strains
Bio Screening - Chalcones - Aurones Analogues - Zoology
591 / B5201
