Synthesis, Characterization and Bioscreening of Isoxazolic Aurone Analogues
Ayesha Kanwal, MPhil(chemistry) 2015-2017 Supervised by Dr.Qamar Ali
Synthesis, Characterization and Bioscreening of Isoxazolic Aurone Analogues /Ayesha Kanwal - Lahore : Department of Chemistry, Div. S&T, University of Education, 2017 - 77 p. xii CD
Several substituted chalcones, aurones and isoxazolic aurones were synthesized. 2'-hydroxy acetophenone and various substituted benzaldehyde were used as precursor to synthesize chalcones. Synthesized chalcones on oxidative cyclization in presence of mercury (II) acetate in pyridine yielded aurones. Respective aurones were treated with hydroxylamine hydrochloride in ethanolic potassium hydroxide to form final
isoxazolic aurones. Synthesized compounds were bioscreened for exhibiting antioxidant activity. Among all, some compounds were found to have potent anti-oxidant activity. Compound 5c was found to exhibit maximum radical scavenging and reduction potential. 7b showed lowest radical scavenging activity while 3c showed lowest reduction potential. Structure of compounds has been confirmed by IR and EIMS.
Characterization - Bioscreening - Isoxazolic - Chemistry
547.2 / Sy78
Synthesis, Characterization and Bioscreening of Isoxazolic Aurone Analogues /Ayesha Kanwal - Lahore : Department of Chemistry, Div. S&T, University of Education, 2017 - 77 p. xii CD
Several substituted chalcones, aurones and isoxazolic aurones were synthesized. 2'-hydroxy acetophenone and various substituted benzaldehyde were used as precursor to synthesize chalcones. Synthesized chalcones on oxidative cyclization in presence of mercury (II) acetate in pyridine yielded aurones. Respective aurones were treated with hydroxylamine hydrochloride in ethanolic potassium hydroxide to form final
isoxazolic aurones. Synthesized compounds were bioscreened for exhibiting antioxidant activity. Among all, some compounds were found to have potent anti-oxidant activity. Compound 5c was found to exhibit maximum radical scavenging and reduction potential. 7b showed lowest radical scavenging activity while 3c showed lowest reduction potential. Structure of compounds has been confirmed by IR and EIMS.
Characterization - Bioscreening - Isoxazolic - Chemistry
547.2 / Sy78
