Inorganic arsenic act as general toxicant and carcinogen. Arsenic contamination causes serious health effects in millions of people around world due to drinking water. Major toxicological effects of arsenic are cancer, neurotoxicity and increased risk of disabled fetuses and loss of fetuses. Aims of present study were to find out various effects of sodium arsenate in evaluating toxicity both in mother and fetal liver, accumulation of arsenic in liver, developmental abnormalities in fetus and protective role of Allium sativum (garlic) to minimize the toxicological effects of sodium arsenate in mice. Dose (0.1 ml of Sodium arsenate) was administered to female mice on 6 th day of gestation for 06 days. The mice were weighed and dissected out at 18th day of getation . Liver of both mother and fetuses were also isolated. Part of half liver tissue was stored in Bouins fixative and half stored for molecular analysis and atomic absorption. In morphological analysis, absence of hind limbs, hard outer skin, resorptions and short growth of fetuses were studied in dose group. High maternal mortality rate and low maternal weight gain was also observed in dose group. In dose + antidote and antidote group, morphologically fetuses were similar to control group. In morphometric analysis, reduced maternal body weight, reduction in crown rump length, body weight and micromelia were studied in dose group. The histological studies on fetal liver of dose group (50mg/kg) showed severe necrosis, binucleated cells and nuclear pyknosis. In maternal liver of dose group, fibrosis, necrosis and increased sinusoidal space were observed. Histological results of dose + antidote group showed minor defects like fat droplets. Maternal and fetal liver of antidote group showed normal strucutre of hepatocytes as in control group. In molecular study, the level of Nrf2 transcription factor significantly increased by the production of oxidative stress due to arsenic in dose group. In dose + antidote group antioxidant response produced by garlic overcame this situation in both mother and fetal liver. Upregulation of ARE-Nrf2-keap1 pathways play a significant role to neutralize deletrious effects generated by arsenic and retain normal processes in body. High arsenic accumulation in both maternal and fetal liver was detected in dose group. In dose + antidote group, a negligible amount of arsenic was detected in maternal liver. Level of arsenic was not detected in fetal liver in dose + antidote and antidote group. These results indicate that sodium arsenate is potential toxin cross placenta and garlic is equally effective in ameliorating these toxicities. Keywords: Sodium arsenate, Allium sativum, Mice, Antidote, Nrf2, Gestation, Liver,Fetus.